Ibogaine research update: phase I human study. Sanchez-Ramos, J. and Mash, D.C. Multidisciplinary Association for Psychedelic Studies 4:11, 1994.

Abstract: We have recently received approval to begin Phase I studies to assess the safety, metabolism and pharmacokinetics of ibogaine in volunteers who have already experienced ibogaine. As of the moment, the effects of 1 mg/kg p.o. have been studied in three volunteers who had previously experienced ibogaine at much higher doses while in Holland. No tremor or ataxia was noted, and no hallucinogenic effects were noted. The subjects felt nothing at all other than perhaps being somewhat calmer than usual. Pharmacokinetic profiling is currently being done with samples of blood taken from these subjects. These results are to be reported to the FDA before commencing with the next dosage level, 2 mg/kg.