Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat.
. Helsley S, Dlugos CA, Pentney RJ, Rabin RA, Winter JC.
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State
University of New York at Buffalo, 14214-3000, USA.
Brain Res 275:753-760, 1997.
Abstract: The present
investigation assessed the chronic toxicity of ibogaine on cerebellar Purkinje cells in male
Fischer 344 rats. A behaviorally active dose of ibogaine (10 mg/kg, i.p.) was administered to
a group of six subjects every other day for 60 days while the control group received an
equivalent volume of saline (1 ml/kg). Estimates of Purkinje cell number were determined using
the optical dissector/fractionator technique. No significant differences in Purkinje cell
number were observed between the ibogaine (243764[+/-32766]) and control groups (230813[+/-16670]).
© 1997The Ibogaine Dossier