NYU Conference on Ibogaine Nov 5-6, 1999
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![]() Mitsogo Bwiti Photo by Gollnhofer
![]() Art Buro, Amsterdam Squatter Movement Prepared for ICASH International Coalition for Addict Self-Help |
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CONTRIBUTORS FOREWORD BY HERB KLEBER PREFACE BY GEOFFREY A. CORDELL PREFACE BY KENNETH R. ALPER AND STANLEY D. GLICK NUMBERING OF IBOGA ALKALOIDS |
ix xv xix xxi xxiii |
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KENNETH R. ALPER
STANLEY D. GLICK, ISABELLE M. MAISONNEUVE AND KAREN K. SZUMLINSKI |
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I. II. III. IV. V. VI. VII. VIII.
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Introduction Behavioral and Neurochemical Methods Opioid Interactions Stimulant Interactions Metabolism and Distribution of Ibogaine and 18-MC Toxicity Mechanisms Discussion References |
39 41 42 45 48 48 49 50 52 |
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Ibogaine as a Glutamate Antagonist: Relevance to Putative Antiaddictive Properties PHIL SKOLNICK
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I. II. III.
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Overview
NMDA Antagonist Properties of Ibogaine Are the NMDA Antagonist Properties of Ibogaine Relevant to its Putative Antiaddictive Properties? References |
55
56 58 61 |
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Drug Discrimination Studies with Ibogaine SCOTT HELSLEY, RICHARD A. RABIN AND J.C. WINTER
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I. II. III.
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Introduction Ibogaine in Drug Discrimination Studies Summary References |
63 65 75 76 |
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Comparative Neuropharmacology of Ibogaine and Its O-Desmethyl Metabolite, Noribogaine MICHAEL H. BAUMANN, JOHN PABLO, SYED F. ALI, RICHARD B. ROTHMAN AND DEBORAH C. MASH
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I. II. III. IV. V. VI.
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Introduction Pharmacokinetics Neurochemical Mechanisms Neuroendocrine Effects Adverse Consequences Conclusions References |
80 82 85 100 103 107 109 |
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Characterization of Multiple Sites of Action of Ibogaine HENRY SERSHEN, AUDREY HASHIM AND ABEL LAJTHA
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I. II. III. IV. V. VI. VII. VIII.
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Introduction Issues Related to Ibogaine in the Treatment of Drug Dependence Effects of Ibogaine on Drug-Induced Behavior Binding Site Activity Functional Activity Stimulant Drug Actions/Behaviors Current Non-Ibogaine Drug Treatment Protocols Conclusions References |
115 117 119 119 122 124 127 129 130 |
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Changes in Gene Expression and Signal Transduction Following Ibogaine Treatment SAMUEL S. ONAIVI, B. EMMANUEL AKINSHOLA, SYED F. ALI
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I. II. III. IV. V.
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Introduction In Vitro Action of Cocaine on Ca2+ and Protein Kinase C Signaling Effects of Ibogaine on the Action of Cocaine in Vivo Expression of Genes Regulated by Ibogaine Using cDNA Micro Analysis Conclusions References |
136 142 146 149 151 152 |
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Ibogaine in the Treatment of Heroin Withdrawal DEBORAH C. MASH, CRAIG A. KOVERA, JOHN PABLO, RACHEL TYNDALE, FRANK R. ERVIN, JEFFREY D. KAMLET AND W. LEE HEARN
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