Table of Contents, The Alkaloids vol 56, Academic Press - Ibogaine Proceedings
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NYU Conference on Ibogaine Nov 5-6, 1999





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The Ibogaine Dossier

The Alkaloids

Volume 56

Edited by Kenneth R. Alper and Stanley D. Glick

Academic Press © 2001

This book available from Academic Press
This book available from Amazon.com
Read Chapter 14: html version
INDEX Now available.

The book Index and chapters are now available as PDF files linked to the Table of Contents.

TABLE of CONTENTS


 

CONTRIBUTORS

FOREWORD BY HERB KLEBER

PREFACE BY GEOFFREY A. CORDELL

PREFACE BY KENNETH R. ALPER AND STANLEY D. GLICK

NUMBERING OF IBOGA ALKALOIDS

 

   ix

  xv

 xix

 xxi

xxiii

 

Ibogaine: A Review

KENNETH R. ALPER

I.

II.

III.

IV.

V.

VI.

VII.

VIII.

IX.

X.

 

Introduction, Chemical Properties and Historical Time Line.

Mechanisms of Action

Evidence of Efficacy in Animal Model

Evidence of Efficacy and Subjective Effects in Humans

Pharmacokinetics

Safety

Learning, Memory and Neurophysiology

Anthropological and Sociological Perspectives

Economic and Political Perspectives

Conclusions

References

 2

 6

 12

 16

 19

 22

 27

 30

 31

 32

 33

 

Mechanisms of Action of Ibogaine: Relevance to Putative Therapeutic Effects and Development of a Safer Iboga Alkaloid Congener

STANLEY D. GLICK, ISABELLE M. MAISONNEUVE AND KAREN K. SZUMLINSKI

 

I.

II.

III.

IV.

V.

VI.

VII.

VIII.

 

 

Introduction

Behavioral and Neurochemical Methods

Opioid Interactions

Stimulant Interactions

Metabolism and Distribution of Ibogaine and 18-MC

Toxicity

Mechanisms

Discussion

References

 

 39

 41

 42

 45

 48

 48

 49

 50

 52

 

Ibogaine as a Glutamate Antagonist: Relevance to Putative Antiaddictive Properties

PHIL SKOLNICK

 

I.

II.

III.

 

Overview

NMDA Antagonist Properties of Ibogaine

Are the NMDA Antagonist Properties of Ibogaine Relevant to its Putative Antiaddictive Properties?

References

 55

 56

 58

 61

 

Drug Discrimination Studies with Ibogaine

SCOTT HELSLEY, RICHARD A. RABIN AND J.C. WINTER

 

I.

II.

III.

 

Introduction

Ibogaine in Drug Discrimination Studies

Summary

References

 63

 65

 75

 76

 

Comparative Neuropharmacology of Ibogaine and Its O-Desmethyl Metabolite, Noribogaine

MICHAEL H. BAUMANN, JOHN PABLO, SYED F. ALI, RICHARD B. ROTHMAN AND DEBORAH C. MASH

 

I.

II.

III.

IV.

V.

VI.

 

Introduction

Pharmacokinetics

Neurochemical Mechanisms

Neuroendocrine Effects

Adverse Consequences

Conclusions

References

 80

 82

 85

100

103

107

109

 

Characterization of Multiple Sites of Action of Ibogaine

HENRY SERSHEN, AUDREY HASHIM AND ABEL LAJTHA

 

I.

II.

III.

IV.

V.

VI.

VII.

VIII.

 

Introduction

Issues Related to Ibogaine in the Treatment of Drug Dependence

Effects of Ibogaine on Drug-Induced Behavior

Binding Site Activity

Functional Activity

Stimulant Drug Actions/Behaviors

Current Non-Ibogaine Drug Treatment Protocols

Conclusions

References

115

117

119

119

122

124

127

129

130

 

Changes in Gene Expression and Signal Transduction Following Ibogaine Treatment

SAMUEL S. ONAIVI, B. EMMANUEL AKINSHOLA, SYED F. ALI

 

I.

II.

III.

IV.

V.

 

Introduction

In Vitro Action of Cocaine on Ca2+ and Protein Kinase C Signaling

Effects of Ibogaine on the Action of Cocaine in Vivo

Expression of Genes Regulated by Ibogaine Using cDNA Micro Analysis

Conclusions

References

136

142

146

149

151

152

 

Ibogaine in the Treatment of Heroin Withdrawal

DEBORAH C. MASH, CRAIG A. KOVERA, JOHN PABLO, RACHEL TYNDALE, FRANK R. ERVIN, JEFFREY D. KAMLET AND W. LEE HEARN

 

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